GDI.v1

GDI: accumulated mutational damage in the general population in human protein-coding genes. It is used to filter out false positive genes (those unlikely to cause disease) that show "HIGH" damage in the disease model of interest and relevant mode of inheritance. Neutrality Index (NI): estimated selective pressure (purifying or positive) on human protein-coding genes.

Input: a list of genes separated by lines, and the disease type of interest
Output: GDI phred score with a low/high prediction according to the disease type, and the selective pressure (neutrality index)
Reference: Itan Y, et al. The human gene damage index as a gene-level approach to prioritizing exome variants. PNAS. 2015.
New Version: GDI.v2